Neurodevelopmental Outcomes Prediction in Newborns with Seizures Caused by <i>KCNQ2</i> Gene Defects

Author:

Huang Zhelan,Liu Bo,Xiao Tiantian,Wang Yaqiong,Lu Yulan,Hu Liyuan,Cheng Guoqiang,Li Zhihua,Wang Laishuan,Zhang Rong,Wang Jin,Cao Yun,Dong Xinran,Yang LinORCID,Zhou Wenhao

Abstract

<b><i>Introduction:</i></b> Pathogenic variant in the <i>KCNQ2</i> gene is a common genetic etiology of neonatal convulsion. However, it remains a question in <i>KCNQ2</i>-related disorders that who will develop into atypical developmental outcomes. <b><i>Methods:</i></b> We established a prediction model for the neurodevelopmental outcomes of newborns with seizures caused by <i>KCNQ2</i> gene defects based on the Gradient Boosting Machine (GBM) model with a training set obtained from the Human Gene Mutation Database (HGMD, public training dataset). The features used in the prediction model were, respectively, based on clinical features only and optimized features. The validation set was obtained from the China Neonatal Genomes Project (CNGP, internal validation dataset). <b><i>Results:</i></b> With the HGMD training set, the prediction results showed that the area under the receiver-operating characteristic curve (AUC) for predicting atypical developmental outcomes was 0.723 when using clinical features only and was improved to 0.986 when using optimized features, respectively. In feature importance ranking, both variants pathogenicity and protein functional/structural features played an important role in the prediction model. For the CNGP validation set, the AUC was 0.596 when using clinical features only and was improved to 0.736 when using optimized features. <b><i>Conclusion:</i></b> In our study, functional/structural features and variant pathogenicity have higher feature importance compared with clinical information. This prediction model for the neurodevelopmental outcomes of newborns with seizures caused by <i>KCNQ2</i> gene defects is a promising alternative that could prove to be valuable in clinical practice.

Publisher

S. Karger AG

Subject

Developmental Biology,Pediatrics, Perinatology and Child Health

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