Author:
Si Yingjian,Luo Rongmu,Qin Maoquan,Du Zhenlan,Zhang Xiaomei,Wang Ya,Chen Wei,Gu Wenjing,Xing Guosheng,Dou Lingsong,Cao Wei,Feng Zhichun
Abstract
<b><i>Introduction:</i></b> This retrospective study aimed to compare a range of conditioning regimens in children with severe aplastic anemia (SAA) undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) at the Seventh Medical Center of PLA General Hospital between January 2008 and June 2017. <b><i>Methods:</i></b> Patients were categorized into the Bu (Bu + Flu + Cy + ATG-F regimen) and control (Flu + Cy + ATG-F) groups, with a median follow-up time after HSCT of 3.5 (range, 3.1–6.2) and 3.7 (3.2–5.9) years in the Bu and control groups, respectively. <b><i>Results:</i></b> No differences were observed between the two groups regarding the median time of peripheral blood neutrophil and platelet engraftment (<i>p</i> = 0.538 and <i>p</i> = 0.491); the 28-day engraftment rates of neutrophils were similar (<i>p</i> = 0.199), although higher for platelets with Bu (<i>p</i> = 0.044). Additionally, graft failure was 0% and 20.0% in the Bu and control groups, respectively (<i>p</i> = 0.004). In both groups, the incidence of grades III–IV (or grades II–IV) acute graft-versus-host disease (GVHD) and chronic GVHD was not significantly different (<i>p</i> > 0.05). Moreover, the 3-year overall survival and failure-free survival did not show significant differences (<i>p</i> = 0.670 and <i>p</i> = 0.908). <b><i>Discussion:</i></b> In children with SAA undergoing allo-HSCT, conditioning regimen with Bu + Flu + Cy + ATG-F is capable of enhancing the myeloablation effect, promoting donor hematopoietic stem cell engraftment, and reducing the graft failure rate. Furthermore, it does not increase the incidence of complications, including GVHD.
Subject
Hematology,General Medicine