Increased Longevity of a Novel Gas Exchanger System for Low-Flow Veno-Venous Extracorporeal CO₂ Removal in Acute Hypercapnic Respiratory Failure

Abstract

<b><i>Introduction:</i></b> Low-flow veno-venous extracorporeal CO₂ removal (ECCO₂R) is an adjunctive therapy to support lung protective ventilation or maintain spontaneous breathing in hypercapnic respiratory failure. Low-flow ECCO₂R is less invasive compared to higher flow systems, while potentially compromising efficiency and membrane lifetime. To counteract this shortcoming, a high-longevity system has recently been developed. Our hypotheses were that the novel membrane system provides runtimes up to 120 h, and CO₂ removal remains constant throughout membrane system lifetime. <b><i>Methods:</i></b> Seventy patients with pH ≤ 7.25 and/or PaCO₂ ≥9 kPa exceeding lung protective ventilation limits, or experiencing respiratory exhaustion during spontaneous breathing, were treated with the high-longevity ProLUNG system or in a control group using the original gas exchanger. Treatment parameters, gas exchanger runtime, and sweep-gas VCO₂ were recorded across 9,806 treatment-hours and retrospectively analyzed. <b><i>Results:</i></b> 25/33 and 23/37 patients were mechanically ventilated as opposed to awake spontaneously breathing in both groups. The high-longevity system increased gas exchanger runtime from 29 ± 16 to 48 ± 36 h in ventilated and from 22 ± 14 to 31 ± 31 h in awake patients (<i>p</i> &#x3c; 0.0001), with longer runtime in the former (<i>p</i> &#x3c; 0.01). VCO₂ remained constant at 86 ± 34 mL/min (<i>p</i> = 0.11). Overall, PaCO₂ decreased from 9.1 ± 2.0 to 7.9 ± 1.9 kPa within 1 h (<i>p</i> &#x3c; 0.001). Tidal volume could be maintained at 5.4 ± 1.8 versus 5.7 ± 2.2 mL/kg at 120 h (<i>p</i> = 0.60), and peak airway pressure could be reduced from 31.1 ± 5.1 to 27.5 ± 6.8 mbar (<i>p</i> &#x3c; 0.01). <b><i>Conclusion:</i></b> Using a high-longevity gas exchanger system, membrane lifetime in low-flow ECCO₂R could be extended in comparison to previous systems but remained below 120 h, especially in spontaneously breathing patients. Extracorporeal VCO₂ remained constant throughout gas exchanger system runtime and was consistent with removal of approximately 50% of expected CO₂ production, enabling lung protective ventilation despite hypercapnic respiratory failure.