TPH1 and 5-HTTLPR Genes Specifically Interact in Opiate Dependence but Not in Alcohol Dependence
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Published:2016
Issue:4
Volume:22
Page:201-209
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ISSN:1022-6877
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Container-title:European Addiction Research
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language:en
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Short-container-title:Eur Addict Res
Author:
Wang Tzu-Yun,Lee Sheng-Yu,Chung Yi-Lun,Chen Shiou-Lan,Li Chia-Ling,Chang Yun-Hsuan,Wang Liang-Jen,Chen Po See,Chen Shih-Heng,Chu Chun-Hsien,Huang San-Yuan,Tzeng Nian-Sheng,Hsieh Tsai-Hsin,Lee I. Hui,Chen Kao Chin,Yang Yen Kuang,Hong Jau-Shyong,Lu Ru-Band
Abstract
Background: Different drug dependencies may have unique genetic vulnerabilities. Changes in serotonin availability and function have been linked to addiction. We investigated whether 2 serotonergic polymorphisms, TPH1 A218C (rs1800532) and 5-HTT-linked promoter region (5-HTTLPR) (rs25531), are differently associated with alcohol or opiate dependence. Methods: Alcohol-dependent patients (n = 292), opiate-dependent patients (n = 309), and healthy controls (n = 301) were recruited from the Han Chinese population in Taiwan. Genotypes of TPH1 A218C and 5-HTTLPR polymorphisms were analyzed using a polymerase chain reaction with restriction fragment length polymorphism. Results: The genotype frequencies of the TPH1 A218C polymorphisms were not significantly different in the 3 groups. The genotype frequencies of the 5-HTTLPR S+ (S/S, S/LG, LG/LG) polymorphisms were significantly higher in opiate-dependent patients (χ2 = 8.77, p = 0.01), but not after controlling for the covariates of age, gender, and interaction effect in logistic regression analysis. Moreover, there was a significant interaction between the TPH1 A218C A/C and 5-HTTLPR S+ gene polymorphisms in opiate-dependent (OR 2.72, p = 0.01), but not in alcohol-dependent patients. Conclusions: Our data suggested that there may be a differential genetic vulnerability in serotonergic genes for alcohol and opiate addiction. However, replications of our findings are still needed.
Subject
Psychiatry and Mental health,Health(social science),Medicine (miscellaneous)
Cited by
3 articles.
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