A Stereotactic Device for Intraparenchymal Spinal Cord Injections: Latest Developments for Practical Clinical Use

Author:

Federici Thais,Hardcastle Nathan,Texakalidis Pavlos,Tora Muhibullah S.,Wetzel JeremyORCID,Riley Jonathan P.,Boulis Nicholas M.

Abstract

This manuscript introduces the latest generation of a patient-mounted platform designed for segmental injections of therapeutics direct into the spinal cord parenchyma. It emphasizes its importance and it presents the rationale for developing this delivery methodology. It compares the newest with the previous generations, detailing how the modifications can streamline transportation, assembly, sterilization, and utilization of the platform by different surgeons. Finally, the illustrations depict the main alterations, as well as a cadaveric assessment of the device prototype in the cervical and thoracolumbar regions.

Publisher

S. Karger AG

Subject

Neurology (clinical),Surgery

Reference16 articles.

1. Lamanna JJ, Miller JH, Riley JP, Hurtig CV, Boulis NM. Cellular therapeutics delivery to the spinal cord: technical considerations for clinical application. Ther Deliv. 2013;4(11):1397–410.

2. Chen KS, McGinley LM, Kashlan ON, Hayes JM, Bruno ES, Chang JS, et al. Targeted intraspinal injections to assess therapies in rodent models of neurological disorders. Nat Protoc. 2019;14(2):331–49.

3. Knoller N, Auerbach G, Fulga V, Zelig G, Attias J, Bakimer R, et al. Clinical experience using incubated autologous macrophages as a treatment for complete spinal cord injury: phase I study results. J Neurosurg Spine. 2005;3(3):173–81.

4. Levi AD, Okonkwo DO, Park P, Jenkins AL 3rd, Kurpad SN, Parr AM, et al. Emerging safety of intramedullary transplantation of human neural stem cells in chronic cervical and thoracic spinal cord injury. Neurosurgery. 2018;82(4):562–75.

5. Kutikov AB, Moore SW, Layer RT, Podell PE, Sridhar N, Santamaria AJ, et al. Method and apparatus for the automated delivery of continuous neural stem cell trails into the spinal cord of small and large animals. Neurosurgery. 2019;85(4):560–73.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3