The Release of Cyclophilin A from Rapamycin-Stimulated Vascular Smooth Muscle Cells Mediated by Myosin II Activation: Involvement of Apoptosis but Not Autophagy

Author:

Su Zizhuo,Lin Maohuan,Zhang Haijun,Li Jiajie,Wu Meiping,Lv Hanlu,Wang Jingfeng,Xie ShuanglunORCID

Publisher

S. Karger AG

Subject

Cardiology and Cardiovascular Medicine,Physiology

Reference27 articles.

1. Seizer P, Ungern-Sternberg SN, Schönberger T, Borst O, Münzer P, Schmidt EM, et al. Extracellular cyclophilin A activates platelets via EMMPRIN (CD147) and PI3K/Akt signaling, which promotes platelet adhesion and thrombus formation in vitro and in vivo. Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):655–63.

2. Nigro P, Satoh K, O’Dell MR, Soe NN, Cui Z, Mohan A, et al. Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice. J Exp Med. 2011 Jan;208(1):53–66.

3. Satoh K, Nigro P, Matoba T, O’Dell MR, Cui Z, Shi X, et al. Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. Nat Med. 2009 Jun;15(6):649–56.

4. Satoh K, Matoba T, Suzuki J, O’Dell MR, Nigro P, Cui Z, et al. Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation. Circulation. 2008 Jun;117(24):3088–98.

5. Satoh K, Satoh T, Kikuchi N, Omura J, Kurosawa R, Suzuki K, et al. Basigin mediates pulmonary hypertension by promoting inflammation and vascular smooth muscle cell proliferation. Circ Res. 2014 Sep;115(8):738–50.

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