Deep Brain Stimulation of the Pallidofugal Pathways to Rescue Severe Life-Threatening Dyskinesias after STN-DBS Lead Implantation

Author:

Avecillas-Chasin Josue M.,Jimenez-Shahed Joohi,Miravite JoanORCID,Bressman Susan,Kopell Brian HORCID

Abstract

We present a patient with severe life-threatening dyskinesias due to a persistent microlesion effect after STN-DBS electrode implantation. The pallidofugal pathways were identified using patient-specific tractography, and steering the current toward this white matter structure resulted in complete resolution of the severe dyskinesias.

Publisher

S. Karger AG

Subject

Neurology (clinical),Surgery

Reference9 articles.

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2. Goftari M, Kim J, Johnson E, Patriat R, Palnitkar T, Harel N, et al. Pallidothalamic tract activation predicts suppression of stimulation-induced dyskinesias in a case study of parkinson’s disease. Brain Stimul. 2020;13(6):1821–3.

3. Sriram A, Foote KD, Oyama G, Kwak J, Zeilman PR, Okun MS. Brittle dyskinesia following STN but not GPi deep brain stimulation. Tremor Other Hyperkinet Mov. 2014 Jun;4:242.

4. Bostan AC, Strick PL. The basal ganglia and the cerebellum: nodes in an integrated network. Nat Rev Neurosci. 2018;19(6):338–50.

5. Avecillas-Chasin JM, Honey CR. Modulation of nigrofugal and pallidofugal pathways in deep brain stimulation for parkinson disease. Neurosurgery. 2020;86(4):E387–97.

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