Association of High-Sensitivity Troponin I with Cardiac and Cerebrovascular Events in Patient after Ischemic Stroke

Abstract

<b><i>Introduction:</i></b> Early recognition and risk stratification of cardiovascular events are necessary in patients after ischemic stroke. Recent evidence suggests that elevated high-sensitive cardiac troponin is a predictor of mortality and vascular events. Therefore, we aimed to explore the prognostic role of high-sensitive cardiac troponin I (hs-TnI) on mortality and cardiovascular outcomes in patients after ischemic stroke. <b><i>Methods:</i></b> From August 2014 to July 2017, 1,506 patients with acute ischemic stroke were pulled consecutively in a retrospective single-center registry. Of these, 1,019 patients were selected and classified into the elevated or non-elevated hs-TnI groups according to hs-TnI level of 99th percentile upper reference limit (URL) at the time of admission for ischemic stroke. The primary outcome was a major adverse cardiac and cerebrovascular event (MACCE) during follow-up. <b><i>Results:</i></b> Among 1,019 patients, 708 patients were non-elevated hs-TnI group (&#x3c;99th percentile URL of hs-TnI) and 311 patients were elevated hs-TnI group (≥99th percentile URL of hs-TnI). The median follow-up period was 22.5 (interquartile range 5.0–38.8) months. In a multivariable Cox regression model, the elevated hs-TnI group has a higher risk of MACCE (adjusted hazard ratio [HR]: 3.12; 95% confidence interval [CI]: 2.33–4.17; <i>p</i> &#x3c; 0.01), all-cause mortality (adjusted HR: 4.15; 95% CI: 2.47–6.99; <i>p</i> &#x3c; 0.01) and readmission caused by coronary revascularization (adjusted HR: 3.12; 95% CI: 1.41–6.90; <i>p</i> &#x3c; 0.01), heart failure (adjusted HR: 2.76; 95% CI: 1.38–5.51; <i>p</i> &#x3c; 0.01), and stroke (adjusted HR: 1.73; 95% CI: 1.07–2.78; <i>p</i> = 0.02) compared with the non-elevated hs-TnI group. <b><i>Conclusions:</i></b> Elevated hs-TnI is independently associated with higher mortality and cardiac and cerebrovascular events in patients with ischemic stroke and may serve as a valuable prognostic factor in management after ischemic stroke.