Focal Epilepsy in Individuals with Laron Syndrome

Abstract

<b><i>Objective:</i></b> The aim of the study was to describe focal epilepsy in patients with Laron syndrome (LS). <b><i>Methods:</i></b> Data were retrieved from medical records of a single-center cohort of 75 patients with LS. <b><i>Results:</i></b> We describe for the first time 4 patients with concomitant focal epilepsy and LS. Two of them experienced episodes of status epilepticus. Electroencephalogram examination in all 4 patients showed interictal epileptiform discharges in the temporal regions. Three achieved long-term seizure freedom on antiseizure medications. <b><i>Conclusion:</i></b> Patients with LS may be at risk of developing focal epilepsy, which seems to be unrelated to hypoglycemic episodes in childhood.