Sisaipho Revisited: Inverse Ophiasis or More than That?

Abstract

<b><i>Introduction:</i></b> Alopecia areata exhibits diverse clinical forms, encompassing the less common variant, sisaipho. Clinical observations suggest its unique ability to emulate both male and female pattern hair loss, implying a potential androgenic influence akin to androgenetic alopecia. <b><i>Case Presentations:</i></b> Herein, we present 3 cases of alopecia areata in adults exhibiting a male or female pattern distribution or accentuation. <b><i>Conclusion:</i></b> To improve diagnosis and differential diagnosis of alopecia, the term “alopecia areata in a male or female pattern distribution” may be introduced as a new clinical subtype of alopecia areata. This new subtype could also integrate sisaipho. By introducing this refined terminology, we seek to improve our comprehension of the condition, enabling more precise diagnoses and tailored treatment approaches.