Serum 25-Hydroxyvitamin D Level Is Negatively Associated with Fatigue in Elderly Maintenance Hemodialysis Patients

Abstract

<b><i>Introduction:</i></b> Chronic kidney disease-mineral and bone disorder (CKD-MBD) is frequently observed in maintenance hemodialysis (MHD) patients and is associated with fracture, muscle weakness, malnutrition, etc.; however, relationships of CKD-MBD markers and fatigue are not well established. <b><i>Methods:</i></b> This was a cross-sectional study including 244 MHD patients (89 elders) from July to September 2021 in the First Affiliated Hospital of Shandong First Medical University. CKD-MBD markers and other clinical data were collected from medical records. Fatigue in the past week was measured by Standardized Outcomes in Nephrology-Hemodialysis (SONG-HD) fatigue measure; fatigue at the end of hemodialysis was measured by numeric rating scale (NRS). Spearman correlation, linear regression, and robust linear regression were. <b><i>Results:</i></b> In all MHD patients, lg[25(OH)D] (nmol/L) was negatively correlated with SONG-HD score (β = −1.503, 95% CI: −2.826 to 0.18, <i>p</i> = 0.026) and NRS score (β = −1.532, <i>p</i> = 0.04) in multiple regression models adjusting for sex, age, and all CKD-MBD characters; but no correlations were found on univariate regression or in other multiple regression models. Interaction effects between age ≥65 years and lg(25[OH]D [nmol/L]) in terms of fatigue scores were significant based on multiple linear regressions (SONG-HD score β = −3.613, <i>p</i> for interaction = 0.006; NRS score β = −3.943, <i>p</i> for interaction = 0.008). Compared with non-elderly patients, elderly patients were with higher ACCI scores (7 [6, 8] vs. 4 [3, 5], <i>p</i> &lt; 0.001), higher SONG-HD scores (3 [2, 6] vs. 2 [1, 3], <i>p</i> &lt; 0.001), higher NRS score (4 [2, 7] vs. 3 [1, 5], <i>p</i> &lt; 0.001), lower serum phosphate levels (1.65 [1.29, 2.10] vs. 1.87 [1.55, 2.26] mmol/L, <i>p</i> = 0.002), and lower serum iPTH levels (160.6 [90.46, 306.45] vs. 282.2 [139, 445.7] pg/mL, <i>p</i> &lt; 0.001). There were no differences in serum calcium, alkaline serum, or 25(OH)D levels between the two groups. In elderly patients, lg[25(OH)D] was negatively correlated with SONG-HD score (β = −3.323, <i>p</i> = 0.010) and NRS score (β = −3.521, <i>p</i> = 0.006) on univariate linear regressions. Following adjustment for sex, age, and all CKD-MBD characters, lg[25(OH)D] was negatively correlated with SONG-HD scores (multiple linear regression β = −4.012, <i>p</i> = 0.004; multiple robust regression β = −4.012, <i>p</i> = 0.003) or NRS scores (multiple linear regression β = −4.104, <i>p</i> = 0.002; multiple robust regression β = −4.104, <i>p</i> = 0.001). There were no significant correlations between fatigue scores and other CKD-MBD markers (calcium, phosphate, lgiPTH, alkaline phosphatase) in elderly MHD patients, on either univariate linear regressions or multiple regressions. <b><i>Conclusion:</i></b> Serum 25(OH)D level is negatively associated with fatigue in elderly MHD patients.