Expression of the α7 Nicotinic Acetylcholine Receptor is Critically Required for the Antifibrotic Effect of PHA-543613 on Skin Fibrosis

Author:

Stegemann Agatha,Raker Verena,del Rey Adriana,Steinbrink Kerstin,Böhm Markus

Publisher

S. Karger AG

Subject

Cellular and Molecular Neuroscience,Endocrine and Autonomic Systems,Endocrinology,Endocrinology, Diabetes and Metabolism

Reference31 articles.

1. Asano Y. Systemic sclerosis. J Dermatol. 2018 Feb;45(2):128–38.

2. Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol. 2008 Jan;214(2):199–210.

3. Leask A, Abraham DJ. TGF-beta signaling and the fibrotic response. FASEB J. 2004 May;18(7):816–27.

4. Yamamoto T, Takagawa S, Katayama I, Yamazaki K, Hamazaki Y, Shinkai H, et al. Animal model of sclerotic skin. I: local injections of bleomycin induce sclerotic skin mimicking scleroderma. J Invest Dermatol. 1999 Apr;112(4):456–62.

5. Moeller A, Ask K, Warburton D, Gauldie J, Kolb M. The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis? Int J Biochem Cell Biol. 2008 Mar;40(3):362–82.

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