The Desert Hedgehog Signalling Pathway in Human Gonadal Development and Differences of Sex Development

Author:

Pachernegg Svenja,Georges Elizabeth,Ayers Katie

Abstract

While the Hedgehog signalling pathway is implicated in numerous developmental processes and maladies, variants in the <i>Desert Hedgehog</i> (<i>DHH</i>) ligand underlie a condition characterised by 46,XY gonadal dysgenesis with or without peripheral neuropathy. We discuss here the role and regulation of <i>DHH</i> and its signalling pathway in the developing gonads and examine the current understanding of how disruption to this pathway causes this difference of sex development (DSD) in humans.

Publisher

S. Karger AG

Subject

Developmental Biology,Embryology,Endocrinology, Diabetes and Metabolism

Reference86 articles.

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