Oral Wheat Immunotherapy: Long-Term Follow-Up in Children with Wheat Anaphylaxis

Abstract

<b><i>Introduction:</i></b> There has been substantial increase in food allergies in recent decades. The management of severe food allergy often includes strict avoidance and medical therapies. However, oral immunotherapy (OIT) is a promising treatment option for these patients, which is still being investigated. <b><i>Methods:</i></b> The study recruited children from 2 years onward with a history of wheat anaphylaxis who had been referred to the Mofid Children Hospital. Wheat allergy was confirmed by a double-blind placebo-controlled food challenge. OIT was started to reach 5.28 g of wheat protein supplied in 60 g of bread. Besides immunologic measurements, a second and third oral food challenge (OFC) was performed after 3 months and 1 year of maintenance therapy to evaluate the long-term efficacy of wheat OIT (WOIT). <b><i>Results:</i></b> Seventeen patients completed the 3-month maintenance phase; 8 of them demonstrated negative OFCs. All of the 9 with positive OFCs were asked to continue the daily consumption of 60 g of bread for another year. Three patients with positive OFCs were followed for 1 more year and were asked to continue eating 60 g of bread every other day. The serum level of wheat sIgE was significantly increased at the end of the buildup phase (<i>p</i> = 0.026) and dramatically dropped at the end of the maintenance phase (<i>p</i> = 0.022). <b><i>Conclusion:</i></b> To conclude, WOIT is an effective and safe modality of treatment if it is administered under strict supervision.