Kronik böbrek hastalığı progresyonunu etkileyen faktörler

Abstract

Aims: Chronic kidney disease (CKD) is characterized by irreversible and progressive loss of renal function. One of the most important goals in CKD management is to delay CKD progression. The aim of this study was to investigate the outcomes of non-dialysing CKD patients, rate of progression of disease and factors associated with CKD progression and mortality. Methods: In this retrospective study, 245 non-dialysis CKD (stage 3-5) patients who presented to nephrology outpatient clinic between December 2013 and June 2015 were included. Patients’ baseline demographic, clinical/laboratory data were obtained. Outcomes of the patients in terms of CKD progression (defined as the initiation of renal replacement therapy or death) between November 2022 and December 2022 were recorded. Results: Patients’ mean age (baseline) was 56±12 years; 116 patients (47.3%) were female. During median 46 months of follow-up period, 42.9% of the patients underwent renal replacement therapy and all-cause mortality rate was 9.8%. Baseline eGFR, proteinuria and having diabetes mellitus as a comorbidity were found to be associated with CKD progression, independently (the risk increases by 75% with each 1 ml/min decrease in eGFR, p