Efficacy of Phytochemical Constituents of Castor Essential oil Towards the Mucor-Mycotic Mold Cunninghamella Bertholletiae-Reference-Cited by-同舟云学术

Efficacy of Phytochemical Constituents of Castor Essential oil Towards the Mucor-Mycotic Mold Cunninghamella Bertholletiae

Published:2020-07-25 Issue:1 Volume:3 Page:1-11
ISSN:2377-2549
Container-title:Journal of New Developments in Chemistry
language:
Short-container-title:JNDC

Author:

Maqbul Muazzam Sheriff¹,Saeed Muaadh Badr²,Dawoud Areej³,Mohammed Tasneem³,Khan Kayamkani Abedulla⁴,Ikbal Abdul Rahman³,Khan Aejaz Abdullatif³,Iqubal S.M. Shakeel³

Affiliation:

1. Faculty of Microbiology and Immunology, Ibn Sina National College of Medical Sciences, Al Mahjar Street: 31906, Jeddah 21418, Kingdom of Saudi Arabia.

2. Medicine Program, Ibn Sina National College of Medical Sciences, Al Mahjar Street: 31906, Jeddah 21418, Kingdom of Saudi Arabia.

3. Department of General Science, Ibn Sina National College of Medical Sciences, Al Mahajar Street: 31906, Jeddah 21418, Kingdom of Saudi Arabia.

4. Department of Clinical Pharmacy & Pharmacology, IbnSina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia.

Abstract

The aim of this experiment is to study the efficacy of phytochemical constituents of Castor essential oil towards the mucor-mycotic mold Cunninghamella bertholletiae.The standard chemical analytical methods were used for the rapid study of the phytochemical constituents responsible for the antimicrobial efficacy of the procured castor essential oil. The standard antimicrobial assay technique employed to study the comparative values of the efficacy of the procured castor essential oil with that of the standard antifungal chemical agents against the clinical isolates obtained from the immune suppressed patients samples of Cunninghamella bertholletia mold mucor-mycotic infections. The best susceptibility values recorded in the standard antifungal agents against the clinical isolates of Cunninghamella bertholletiae was with Amphotericin B showing the average zone of inhibition diameter of 20.66 mm with the average MIC value of, 1.66 (µ/ml) but the antimicrobial assay results for the Castor essential oil showed better values with an average disc diffusion of 22.44mm zone of inhibition diameter with average MIC value of 1.72 µ/ml .This study has shown that the phytochemical compounds present in the Castor essential oil proves to be more an effective alternative antifungal substance towards the clinical isolates of Cunninghamella bertholletiae.

Publisher

Open Access Pub

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