Evaluation of some Herbal Agents in the treatment of Diabetes in Comparison to Insulin

Abstract

We conducted an experimental investigation in which hyperglycemia was created in rats using Alloxan; we then employed an herbal drug that could reverse the hypoglycemic effects of insulin, which is to say, we used Alloxan to induce hyperglycemia in the rats. Research conducted on 24 Black rats over 28 days (split into four groups of six rats each on days 1, 7, 14, and 28) shows that ALLOXAN can induce hyperglycemia with statistical significance (P0.0001). HERBAL DRUGS (Momordica Charantia L) have effectively reduced hyperglycemia brought on by Alloxan, with statistically significant results (P0.0001) but not as strong as those produced by insulin. Momordica Charantia L for its insulin-like effects on blood sugar levels in the context of hyperglycemia produced by Alloxan. Through the use of "Black rats," we were able to successfully visualize a model for inducing hyperglycemia via intraperitoneal injection of ALLOXAN. The effectiveness of Momordica charantia L in bringing down hyperglycemia was then compared to that of insulin. Comparing Momordica charantia L to insulin for the treatment of type 1 diabetes in rats, the following results were found: - On days 7, 14, 21, and 28, with a total of 6 animals (Black rats) in each group, the mean S.D. of the hypoglycemic effect of Momordica charantia L was (148.42 +/-3.65), (127.66 +/- 2.520), (95.78 +/-1.18), and (86.54 +/3.55). To put it another way, the herbal remedy effectively lowers blood sugar levels in those who suffer from hyperglycemia. The present findings highlight that Momordica charantia L effectively treats type 1 diabetes mellitus in rats and has the same effect on blood glucose levels as pharmaceutical insulin. Keywords: Alloxan, Hypoglycemia, Insulin, Momordica charantia L, Hyperglycemia.