Myasthenia Gravis in the Neonate

Author:

Hassoun Mossaab1,El Turjuman Ulfat2,Chokr Imad3,Fakhoury Hassan4

Affiliation:

1. Neonatology Fellow.

2. Pediatric Neurologist.

3. Head, Neonatology Division.

4. Chairman, Pediatrics Department, Rafic Hariri University Hospital, Beirut, Lebanon (affiliated with the American University of Beirut and Lebanese University, Lebanon).

Abstract

Myasthenia gravis (MG) in the neonate is usually an autoimmune disorder, although some neonates have congenital MG, which most commonly seems to be due to an autosomal recessive disorder. The most common form of MG in the neonate is transient and results from placentally transferred antibodies to acetylcholine. In this article, we review MG affecting both mothers and infants and use a case of transient neonatal MG to demonstrate the clinical features of the disorder. The infant was born to an apparently asymptomatic mother.

Publisher

American Academy of Pediatrics (AAP)

Subject

Pediatrics, Perinatology and Child Health

Reference12 articles.

1. Treatment of autoimmune myasthenia gravis;Richman;Neurology,2003

2. Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies;Hoch;Nat Med,2001

3. Treatment of myasthenia gravis;Toyka;Schweiz Arch Neurol Psychiatr,2007

4. Myasthenia gravis and pregnancy: clinical implications and neonatal outcome;Téllez-Zenteno;BMC Musculoskelet Disord,2004

5. Acute neuromuscular diseases and disorders;Weimer,2005

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