Affiliation:
1. Clinique Universitaire de Pédiatrie and Laboratoire de Physiopathologie Clinique, University of Geneva, Switzerland
Abstract
Experiments were undertaken to study simultaneously plasma renin activity (PRA) and aldosterone secretion (Aldo-SR) in seven patients with congenital adrenal hyperplasia (CAH), aged 5 months to 12 years, and four normal subjects. Control values of renin on a liberal salt intake in 28 children were 19 ± 16 ng/l/minute, which is considerably higher than in adults (9 ± 7.6 ng/l/minute).
Of the seven patients, four had PRA levels between 26 and 39 ng/l/minute. The other three had levels of 115, 249, and 1,250 ng/l/minute on a liberal salt intake. Aldo-SR was between 131 and 264 µg/24 hours in four subjects and was low in two (12 and 37 µg/24 hours).
Salt restriction increased PRA 3.5 to five times in four patients, compared with two times in four normal subjects. Despite the high renin values, Aldo-SR increased at the utmost threefold, compared with a four- to eightfold increase in the normal children. That discrepancy between PRA and Aldo-SR points to a defect in aldosterone synthesis in all forms of CAH.
PRA and Aldo-SR were both lowered by steroid therapy.
Publisher
American Academy of Pediatrics (AAP)
Subject
Pediatrics, Perinatology and Child Health
Cited by
5 articles.
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1. Current concepts in congenital adrenal hyperplasia;Genetic Disorders, Syndromology and Prenatal Diagnosis;1982
2. The Adrenal Cortex;Contemporary Endocrinology;1979
3. The diagnosis and management of disorders of aldosterone production;Pharmacology & Therapeutics. Part C: Clinical Pharmacology and Therapeutics;1976-01
4. Adrenal Cortex;Clinical Endocrinology;1974
5. Role of Androgens in Growth and Development of the Fetus, Child and Adolescent*;Advances in Pediatrics;1972