Transient Hypothyroxinemia of Prematurity

Author:

La Gamma Edmund F.1,Korzeniewski Steven J.2,Ballabh Praveen3,Paneth Nigel4

Affiliation:

1. Division of Newborn Medicine, Department of Pediatrics, Biochemistry and Molecular Biology, New York Medical College and the Regional Neonatal Center, Maria Fareri Children’s Hospital at Westchester Medical, Valhalla, NY.

2. Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI; Department of Epidemiology and Biostatistics and Program in Public

3. Division of Newborn Medicine, Department of Pediatrics, Cell Biology and Anatomy, New York Medical College and the Regional Neonatal Center, Maria Fareri Children’s Hospital at Westchester Medical, Valhalla, NY.

4. Departments of Epidemiology and Biostatistics, and Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, MI.

Abstract

Thyroid hormones play an important role in central nervous system development, starting from the exclusive maternal contribution in the first trimester and transitioning to a fully independent servo-control system at term birth. Extremely preterm delivery before 28 weeks’ gestational age disrupts this normal transition and reveals the challenge of whether replacement hormone will benefit cognitive and motor development. Although the evidence regarding deficiency is compelling, the hormone replacement question remains unanswered for preterm neonates.

Publisher

American Academy of Pediatrics (AAP)

Subject

Pediatrics, Perinatology and Child Health

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