Fecal Microbiota Transplantation: Information for the Pediatrician
Author:
Oliva-Hemker Maria1, Kahn Stacy A.2, Steinbach William J.3, Cohen Mitchell B., Brumbaugh David, Cole Conrad, Dotson Jennifer L., Harpavat Sanjiv, Lightdale Jenifer R., Mallon Daniel, Oliva-Hemker Maria M., Burrowes Debra L., Maldonado Yvonne A., O’Leary Sean T., Ardura Monica I., Banerjee Ritu, Bryant Kristina A., Campbell James D., Caserta Mary T., John Chandy C., Gerber Jeffrey S., Kourtis Athena P., Ratner Adam J., Romero José R., Shah Samir S., Zangwill Kenneth M., Steinbach William J., Kimberlin David W., Barnett Elizabeth D., Lynfield Ruth, Sawyer Mark H., Bernstein Henry H., Cohn Amanda C., Farizo Karen M., Kafer Lisa M., Kim David, López Medina Eduardo, Moore Denee, Panagiotakopoulos Lakshmi, Sauvé Laura, Silverman Neil S., Starke Jeffrey R., Tomashek Kay M., Frantz Jennifer M., ,
Affiliation:
1. aDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Johns Hopkins University School of Medicine, Baltimore, Maryland 2. bFMT and Microbial Therapeutics Program, Boston Children’s Hospital, Department of Pediatrics, Harvard Medical School, Cambridge, Massachusetts 3. cDepartment of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children’s, Fayetteville, Arkansas
Abstract
Fecal microbiota transplantation (FMT) involves the delivery of an entire microbial community from a healthy donor to a recipient with the intention of ameliorating or curing a specific disease. Current evidence strongly supports a role for FMT in the treatment of Clostridiodes difficile infection, with cure rates of approximately 80% to 90%. This success has led to increasing attention for FMT as a potential therapeutic intervention for other conditions associated with disturbances of the intestinal microbiome, including inflammatory bowel diseases, autism spectrum disorder, and obesity. This clinical report endorses the joint society statement by the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, and the European Society for Pediatric Gastroenterology, Hepatology and Nutrition and is meant to provide the general pediatrician with a broad overview to enable appropriate guidance to families seeking FMT as treatment of a child’s condition.
Publisher
American Academy of Pediatrics (AAP)
Subject
Pediatrics, Perinatology and Child Health
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