In Situ Hybridization Detection of Human Herpesvirus 6 in Brain Tissue From Fatal Encephalitis-Reference-Cited by-同舟云学术

In Situ Hybridization Detection of Human Herpesvirus 6 in Brain Tissue From Fatal Encephalitis

Published:2000-02-01 Issue:2 Volume:105 Page:431-433
ISSN:1098-4275
Container-title:Pediatrics
language:en
Short-container-title:

Author:

Ahtiluoto Satu¹,Mannonen Laura¹,Paetau Anders²,Vaheri Antti¹,Koskiniemi Marjaleena¹,Rautiainen Paula,Muttilainen Marketta

Affiliation:

1. Departments of Virology and

2. Pathology

Abstract

A 23-month-old girl died after 2 days' illness with rash, fever, and convulsions. Neuropathologic findings were consistent with viral hemorrhagic encephalitis in pontine tegmentum and medial thalamic areas. Human herpesvirus 6 (HHV-6) DNA was detected in pontine nuclei by in situ hybridization. In addition, polymerase chain reaction for HHV-6 of serum and paraffin-embedded pontine tissue was positive, and serology indicated an acute primary infection. This is the first case showing HHV-6 DNA in the brain cells of an immunocompetent patient with acute encephalitis.

Publisher

American Academy of Pediatrics (AAP)

Subject

Pediatrics, Perinatology, and Child Health

Link

https://publications.aap.org/pediatrics/article-pdf/105/2/431/887841/pe020000431p.pdf

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