Metabolic Bone Disease of Prematurity

Author:

Moreira Alvaro1,Jacob Rachel2,Lavender Libby2,Escaname Elia3

Affiliation:

1. Department of Pediatrics, Division of Neonatology, University of Texas Health Science Center, San Antonio, TX.

2. Division of Neonatal Intensive Care Unit, University Health System, San Antonio, TX.

3. Division of Pediatric Endocrinology, University of Texas Health Science Center, San Antonio, TX.

Abstract

Advances in neonatal care have led to increased survival rates in preterm infants. Optimizing postnatal nutrition has been a critical factor for improved growth and outcomes in very low-birth-weight infants. Despite rapid progress in the field, obtaining comparable mineral delivery to fetal rates has been challenging. Metabolic bone disease of prematurity is a multifaceted condition primarily resulting from inadequate mineral supply compounded by chronic illness, an immature digestive system, and hormonal imbalance. The aim of this review is to discuss the pathophysiology, diagnosis, prevention, and treatment of metabolic bone disease.

Publisher

American Academy of Pediatrics (AAP)

Subject

Pediatrics, Perinatology, and Child Health

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