Platelet-rich plasma treatment for knee osteoarthritis: A systematic investigation

Abstract

According to indicates, “platelet-rich plasma (PRP)” is efficient, including secure biological technique for handling knee “osteoarthritis (OA)." Considering the number of injections necessary to see the beneficial impact, however, an agreement has yet to be reached. The therapeutic effectiveness of a single PRP injection versus numerous injections in "randomized controlled trials (RCTs)" for OA knee. To examine the impact of single vs. many treatments of PRP for suffering and functioning in patients with knee OA, extensive searching was done for RCTs published between 1970 and 2019. The information systems “MEDLINE, Scopus, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials” were searched. Data on patients, interventions, comparisons, and meaningful outcomes were collected using a data extraction tool to contain research bibliographic material. The statistics regarding the immediate results were combined using a random effects framework. With a low-moderate risk of bias and 301 patient reports, we considered clinical studies. Six months following the treatment, a synthesis revealed no substantial variations between solo and repeated injections about suffering relief standardized, average variance. The effectiveness of the knee significantly improved after numerous injections. The considerable boost was only discernible for the outcomes of solo vs. multiple pills, according to a sub-analysis. Our findings showed that a single PRP injection was just as successful in reducing inflammation as numerous treatments. However, after six months, several therapies appeared more beneficial than a single injection in improving joint functioning. The available data still needs to be improved, and further study on this subject is necessary to support our findings.