Author:
Tamaoka A.,Miyatake F.,Matsuno S.,Ishii K.,Nagase S.,Sahara N.,Ono S.,Mori H.,Wakabayashi K.,Tsuji S.,Takahashi H.,Shoji S.
Abstract
Article abstract Thiobarbituric acid–reactive substances (TBARS), an index of lipid peroxidation, were assayed in postmortem brain. Basal TBARS levels were increased and oxidative stimulation produced more TBARS in AD relative to control brains. In addition, apolipoprotein E isoforms showed differing antioxidant activities, with E2 > E3 > E4, suggesting that the lowest antioxidant activity of E4 could contribute to its association with AD.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Cited by
66 articles.
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