CYP1A1 rs464903 increased the risk of undifferentiated type nasopharyngeal carcinoma among the Balinese population

Abstract

Introduction: Nasopharyngeal carcinoma is a tumor that arises from epithelial cells covering the surface of the nasopharynx. In terms of malignancy, NPC is number 1 in the OHNS and number 5 in Indonesia. Certain risk factors that can predispose an individual to NPC include an EBV infection, salted fish consumption, and smoking. Previous studies also show that the polymorphism of CYP1A1 rs4646903 affect the risk factor and mechanism of NPC incidence. Methods: This is a case-control study conducted at Prof. dr. I.G.N.G. Ngoerah General Hospital, Denpasar. The study used 62 samples. The sample then underwent DNA isolation and amplification using PCR and afterward, visualization, DNA sequencing, and analysis. Results: Bivariate analysis shows that CYP1A1 have a significant relationship with NPC incidence with a p-value of 0.007 (OR: 1.48 ; 95% CI 4.87 (1.5-15.9)). Conclusions: The polymorphisms of CYP1A1 rs4646903 is proven to be the risk factors in the mechanism of undifferentiated NPC among the Balinese population.