Synthesis, Characterization and Molecular Docking of Bis-(1-(2,4-dichlorobenzoyl)-3-methylthiourea) Iron (III) Complex as Anticancer Candidate-Reference-Cited by-同舟云学术

Synthesis, Characterization and Molecular Docking of Bis-(1-(2,4-dichlorobenzoyl)-3-methylthiourea) Iron (III) Complex as Anticancer Candidate

Published:2024-05-21 Issue:6 Volume:27 Page:258-264
ISSN:2597-9914
Container-title:Jurnal Kimia Sains dan Aplikasi
language:
Short-container-title:J. Kim. Sains Apl.

Author:

Ruswanto Ruswanto¹^ORCID,Sandria Feri¹,Wulandari Winda Trisna¹^ORCID,Mardianingrum Richa²

Affiliation:

1. Faculty of Pharmacy, Universitas Bakti Tunas Husada, Tasikmalaya, West Java, Indonesia

2. Department of Pharmacy, Faculty of Health Science, Universitas Perjuangan, Tasikmalaya 46115, West Java, Indonesia

Abstract

The Bis-(1-(2,4-dichlorobenzoyl)-3-methylthiourea) iron (III) complex has been synthesized from the reaction between 1-(2,4-dichlorobenzoyl)-3-methylthiourea and Fe (III) metal ion by reflux method with ethanol solvent at a temperature of 75°C for 7 hours. It was characterized by a hot stage microscope (HSM), UV-Vis, FT-IR, and mass spectroscopy. The % yield of the synthesis result was 97.58%. From the docking study on the ribonucleotide reductase enzyme, the binding affinity value was -7.76 kcal/mol, and the inhibition constant was 2.11 mM. The Bis-(1-(2,4-dichlorobenzoyl)-3 methylthiourea) iron (III) complex compounds can be synthesized and predicted as anticancer candidates.

Publisher

Institute of Research and Community Services Diponegoro University (LPPM UNDIP)

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