Identification of significant protein in protein-protein interaction of Alzheimer disease using top-k representative skyline query-Reference-Cited by-同舟云学术

Identification of significant protein in protein-protein interaction of Alzheimer disease using top-k representative skyline query

Published:2021-04-24 Issue:3 Volume:9 Page:126-132
ISSN:2338-0403
Container-title:Jurnal Teknologi dan Sistem Komputer
language:
Short-container-title:J. Teknol. dan Sist. Komput

Author:

Diansyah Mohammad Romano¹,Kusuma Wisnu Ananta¹²^ORCID,Annisa Annisa¹

Affiliation:

1. Department of Computer Science, Faculty of Mathematics and Natural Sciences, IPB University. Jl. Meranti Wing 20 Level 5, Kampus IPB Darmaga, Bogor 16680, Indonesia

2. Tropical Biopharmaca Research Center, IPB University. Jl. Taman Kencana No. 3, Bogor 16128, Indonesia

Abstract

Alzheimer's disease is the most common neurodegenerative disease. This study aims to analyze protein-protein interaction (PPI) to provide a better understanding of multifactorial neurodegenerative diseases and can be used to find proteins that have a significant role in Alzheimer's disease. PPI data were obtained from experimental and computational predictions and analyzed using centrality measures. The Top-k RSP method was applied to find significant proteins in PPI networks using the dominance rule. The method was applied to the PPI data with the interaction sources from the experimental and experiment+prediction. The results indicate that APP and PSEN1 are significant proteins for Alzheimer's disease. This study also showed that both data sources (experiment+prediction) and the Top-k RSP algorithm proved useful for PPI analysis of Alzheimer's disease.

Funder

Ministry of Research, Technology, and Higher Education

Publisher

Institute of Research and Community Services Diponegoro University (LPPM UNDIP)

Subject

General Earth and Planetary Sciences,General Environmental Science

Reference36 articles.

1. Current understanding of Alzheimer’s disease diagnosis and treatment

2. Parkinson's Disease and Parkinsonism

3. Functional profiling of the Saccharomyces cerevisiae genome

4. Towards the prediction of essential genes by integration of network topology, cellular localization and biological process information

5. A New Method for Identifying Essential Proteins Based on Network Topology Properties and Protein Complexes

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