The role of miRNAs in the pathogenesis of venous thromboembolic comlications

Abstract

Diagnosis of pulmonary embolism (PE), chronic thromboembolic pulmonary hypertension (CTEPH) and other prothrombotic complications remains a challenge due to various clinical manifestations. In recent years, numerous studies have focused on finding reliable biomarkers to confirm pathology. It was shown that microRNAs (miRNAs) regulate gene expression in a wide range of pathophysiological processes, and their profile can change in different cardiovascular diseases. miRNAs are involved in many biological processes, including proliferation, apoptosis and cell differentiation, and angiogenesis. Therefore, circulating miRNAs are considered as new biomarkers. The paper presents basic information on the role of microRNA in the genesis of PE and postthromboembolic complications.