Drug Solubility and Dissolution Thermodynamic Approach in Various Solvents at Different Temperatures: A Review

Abstract

In chemical science, pharmaceutical, food science, petrochemicals, and material science, the solubility parameter is one of the most important factors. The studies of solubility and thermodynamics properties are directly used in crystallization-recrystallization, purification of yields, low toxicity of solvent or green solvent, modification, and many more. The experimental mole fraction solubility of compounds may be determined by various methods such as static gravity, laser dynamic, isothermal equilibrium, shake flask, and a number of other ways. The present review is focusing on the shake flask method. Further, the experimental mole fraction solubility was correlated with a theoretical model such as the Appellate and Buchowski equations. With the help of model correlation such as the Relative Average Deviation (RAD), Absolute Relative Deviation (ARD), and Root Mean Square Deviation (RMSD) for prediction of the best model fitting in theoretical approach. The Van't Hoff equation is most effective in the prediction of the dissolution thermodynamic factors such as ∆H°(mixing enthalpy change), ∆G°(mixing Gibbs energy change), and ∆S°(mixing entropy change). It had been given consequence details about endothermic or exothermic and entropy drive, which was directly applied in industrial production and purification of the drug.