Design and Synthesis of Three Tetracyclic-Dione Derivatives and their Biological Activity on Perfusion Pressure Using an Isolated Rat Heart Model

Abstract

Several tetracyclic derivatives have been prepared with different biological activity; however, there are few reports on the effects exerted by the tetracyclic derivatives on the cardiovascular system. The objective of this investigation was to prepare three tetracyclic-dione derivatives (compounds 3 to 5) to evaluate their biological activity on perfusion pressure and coronary resistance. The first stage was achieved by the synthesis of three tetracyclic‐dione analogs using some chemical strategies. The second stage involves evaluating biological activity from tetracyclic‐derivatives on perfusion pressure and coronary resistance using an isolated rat heart model. The results showed that only compound 5 increases perfusion pressure and coronary resistance compared with the control conditions. In conclusion, the biological activity of compound 5 exerted against perfusion pressure and coronary resistance depends on the functional groups involved in their chemical structure.