Docking of Carboplatin towards Chosen Nanostructures
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Published:2022-03-24
Issue:2
Volume:13
Page:109
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ISSN:2069-5837
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Container-title:Biointerface Research in Applied Chemistry
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language:en
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Short-container-title:Biointerface Res Appl Chem
Abstract
Carboplatin and the closely associated Cisplatin functioning as antitumor agents are among the main platinum-based drugs with wide application in treating various types of cancer. It directly interacts with DNA, which leads to inducing programmed cell death. The theoretical research shows that similar to the nucleobases Adenine or Guanine, Carboplatin and Cisplatin can bind with other chemical compounds, such as B vitamins containing aromatic rings with long pair orbit on the nitrogen atom. It has been proved that vitamins B6 (pyridoxal phosphate) and B3 (niacin) can form complexes with Carboplatin (not only with Cisplatin), which was proven in early theoretical studies. Therefore, creating a drug carrier by complexation Carboplatin with a nanostructure seems appropriate. In this research, the behavior of Carboplatin with Rhombellane homeomorphs and functionalized fullerenes C60 was studied.
Publisher
AMG Transcend Association
Subject
Molecular Biology,Molecular Medicine,Biochemistry,Biotechnology