Abstract
The quinolone drugs such as ciprofloxacin, norfloxacin, and levofloxacin are well-known antibacterial agents with low cytotoxic activity. However, modifying these drugs could improve their cytotoxic activity against cancer cells and switch their potential towards anticancer activity. We describe the chromanone oxime analogs of ciprofloxacin, norfloxacin, and levofloxacin as potential cytotoxic agents. The cytotoxic activity of target compounds (A-F) was evaluated against two cancer cell lines (HepG2, hepatocellular liver carcinoma, and CT26, Murine colon carcinoma) and a normal epithelial cell line, namely CHO (Chinese hamster ovary) by using MTT colorimetric assay. Furthermore, the binding properties of the representative analog (norfloxacin derivative) were investigated by docking study and molecular dynamics simulation.
Publisher
AMG Transcend Association
Subject
Molecular Biology,Molecular Medicine,Biochemistry,Biotechnology