Review of a series of clinical observations of the use of "Cell culture for substitution therapy"

Abstract

Introduction. The necessity to develop new substitutional medical technologies is associated with a high demand for rehabilitative measures of traumatological, surgical, and dental patients and persons with burn disease. The existing clinical practice of using allogeneic and autogenous cells, previously used for these purposes, has not yet been standardized. The aim of the study was to summarize scientific literature data on the clinical effectiveness of cell-based medical biotechnologies for regenerative medicine. Materials and methods. The authors reviewed 29 published scientific sources on the results of clinical trials of the preparation "Cell culture for substitution therapy" in 12 medical institutions of the Ural and Siberian regions of the Russian Federation during the period from 1998 to 2012. Results and discussion. Developed and effectively tested on the basis of medical institutions of Sverdlovsk, Chelyabinsk, Tyumen, Kemerovo regions, the Republic of Sakha (Yakutia) and Khanty-Mansi Autonomous Okrug immunobiological preparation "Cell culture for replacement therapy" had high clinical effectiveness in pathological conditions associated with tissue damage in patients with burns, surgery, trauma and dental profile. The studies demonstrated the key activity of allogeneic fibroblasts in the lesion nidus while reducing the time of extracellular matrix formation during active tissue regeneration. The use of the drug prevented the development of generalized infectious-inflammatory complications, reduced the risk of secondary infections, reduced the period of hospitalization and rehabilitation of patients. Conclusion. Analysis of the literature data on the high efficiency of immunobiological agents for substitution therapy on the example of using the preparation on the basis of allogeneic human fibroblasts, based on modern medical standardization and ethical norms, sets the actual task of their replacement by xenogenic and autologous preparations, which will increase the efficiency and safety of the presented method of treatment, improve the quality, life expectancy and demographic indicators in Russia.