Affiliation:
1. Tula State University; Federal Scientific and Clinical Centre for Specialized Medical Care and Medical Technologies; VITROMED Co.
2. Tula State University
3. Federal Scientific and Clinical Centre for Specialized Medical Care and Medical Technologies; DiaLab+ Co.
4. DiaLab+ Co.
Abstract
Measurement of vitamin D has increased significantly in recent years. Most studies focused on 25(OH)D, which is considered the best indicator of vitamin D status, while there is now more interest in the combined measurement of several clinically significant vitamin D metabolites using the LC–MS/MS technique, which allows simultaneous determination of various vitamin D metabolites over a wide dynamic range. Multi-panel LC–MS/MS analyses are likely to improve future research on the optimal combination of metabolites to assess vitamin D sufficiency, as well as help us better understand its metabolism in normal and pathological changes in the human body. The review examines current trends in analytical determination of vitamin D status and their application in clinical studies.
Subject
Materials Chemistry,Economics and Econometrics,Media Technology,Forestry
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