Effect of Chlorothiazide on Response of Renal Vascular Bed to Vasoactive Substances

Author:

Gillenwater Jay Y.1,Scott Jerry B.1,Frohlich Edward D.1

Affiliation:

1. Physiology Division, U. S. Army Medical Research Laboratory, Fort Knox, Kentucky

Abstract

In the anesthetized dog, administration of an isosmotic solution of chlorothiazide into the renal artery failed to affect renal vascular resistance but did acutely attenuate the constriction produced by intra-arterial injection of l -epinephrine, levarterenol, and Val-5-angiotensin II and potentiated the dilation produced by intra-arterial injection of MgCl 2 .

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Reference9 articles.

1. Effect of Chlorothiazide on Vascular Reactivity.

2. Altered vascular responsiveness following chlorothiazide or mercurial diuresis in norniotensive subjects;WANKO A.;Circulation,1958

3. Influence of Chlorothiazide upon Arterial Responsiveness to Nor-Epinephrine in Hypertensive Subjects

4. Effect of chlorothiazide on norepinephrine response in human hypertension;MERRILL J. P.;Clin. Ees.,1958

5. MECHANISM OF THE ALTERED BLOOD PRESSURE RESPONSIVENESS PRODUCED BY CHLOROTHIAZIDE *

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