Extracorporeal Circulation: A Device for the Quantitative Study of Thrombus Formation in Flowing Blood-Reference-Cited by-同舟云学术

Extracorporeal Circulation: A Device for the Quantitative Study of Thrombus Formation in Flowing Blood

Published:1963-05 Issue:5 Volume:12 Page:441-448
ISSN:0009-7330
Container-title:Circulation Research
language:en
Short-container-title:Circulation Research

Author:

DOWNIE H. G.¹,MURPHY E. A.¹,ROWSELL H. C.¹,MUSTARD J. F.¹

Affiliation:

1. Department of Physiological Sciences, Ontario Veterinary College, Guelph, Department of Medicine, University of Toronto, Sunnybrook Hospital, Department of Veterans Affairs Toronto, Canada

Abstract

A standardized extracorporeal shunt system has been described. It allows examination of the sequence of events in thrombus formation and it provides a means of quantitating it in flowing blood. It further allows assessment to be made of the usefulness of classical in vitro clotting tests in thrombogenesis. The platelet adhesive index and clotting time in silicone showed the best correlation with the amount of thrombus formed. Pig serum presumably rich in serum thrombotic accelerator (STA) has been shown to enhance thrombus formation from flowing blood. Within the limits of these experiments, the rate of blood flow has been found to be of little importance.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Link

https://www.ahajournals.org/doi/pdf/10.1161/01.RES.12.5.441

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