Inducible Pluripotent Stem Cell–Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1 -Associated Noonan Syndrome-Reference-Cited by-同舟云学术

Inducible Pluripotent Stem Cell–Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1 -Associated Noonan Syndrome

Published:2019-07-16 Issue:3 Volume:140 Page:207-224
ISSN:0009-7322
Container-title:Circulation
language:en
Short-container-title:Circulation

Author:

Jaffré Fabrice¹²³,Miller Clint L.⁴,Schänzer Anne⁵,Evans Todd³,Roberts Amy E.⁶,Hahn Andreas⁷,Kontaridis Maria I.¹⁸²⁹¹⁰

Affiliation:

1. Department of Medicine, Division of Cardiology, Beth Israel Deaconess Medical Center (F.J., M.I.K.)

2. Harvard Medical School, Boston, MA (F.J., M.I.K.).

3. Department of Surgery, Weill Cornell Medical College, New York, NY (F.J., T.E.).

4. Center for Public Health Genomics, Department of Public Health Sciences, Biochemistry and Molecular Genetics, and Biomedical Engineering, University of Virginia, Charlottesville (C.L.M.).

5. Institute of Neuropathology (A.S.), University Hospital Giessen, Justus Liebig University Giessen, Germany.

6. Department of Cardiology, Division of Genetics, Boston Children’s Hospital, MA (A.E.R.).

7. Department of Child Neurology (A.H.), University Hospital Giessen, Justus Liebig University Giessen, Germany.

8. Department of Biological Chemistry and Molecular Pharmacology (M.I.K.)

9. Harvard Stem Cell Institute, Harvard University, Cambridge, MA (M.I.K.).

10. Masonic Medical Research Institute, Utica, NY (M.I.K.).

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference50 articles.

1. Noonan syndrome