Affiliation:
1. Heart Institute Hospital Universitari Germans Trias i Pujol Badalona Spain
2. CIBER Enfermedades Cardiovasculares (CIBERCV) Badalona Spain
3. Grup d’Epidemiologia i Genètica Cardiovasculars (EGEC) REGICOR Study Group IMIM (Institut Hospital del Mar d’Investigacions Mèdiques) Barcelona Spain
4. Catalan Health Service Generalitat de Catalunya Barcelona Spain
5. Department of Medicine Autonomous University of Barcelona Barcelona Spain
Abstract
Background
Coronary artery disease remains a major cause of death despite better outcomes of ST‐segment–elevation myocardial infarction (STEMI). We aimed to analyze data from the Ruti‐STEMI registry of in‐hospital, 28‐day, and 1‐year events in patients with STEMI over the past 3 decades in Catalonia, Spain, to assess trends in STEMI prognosis.
Methods and Results
Between February 1989 and December 2017, a total of 7589 patients with STEMI were admitted consecutively. Patients were grouped into 5 periods: 1989 to 1994 (period 1), 1995 to 1999 (period 2), 2000 to 2004 (period 3), 2005 to 2009 (period 4), and 2010 to 2017 (period 5). We used Cox regression to compare 28‐day and 1‐year STEMI mortality and in‐hospital complication trends across these periods. Mean patient age was 61.6±12.6 years, and 79.3% were men. The 28‐day all‐cause mortality declined from period 1 to period 5 (10.4% versus 6.0%;
P
<0.001), with a 40% reduction after multivariable adjustment (hazard ratio [HR], 0.6; 95% CI, 0.46–0.80;
P
<0.001). One‐year all‐cause mortality declined from period 1 to period 5 (11.7% versus 9.0%;
P
=0.001), with a 24% reduction after multivariable adjustment (HR, 0.76; 95% CI, 0.60–0.98;
P
=0.036). A significant temporal reduction was observed for in‐hospital complications including postinfarct angina (−78%), ventricular tachycardia (−57%), right ventricular dysfunction (−48%), atrioventricular block (−45%), pericarditis (−63%), and free wall rupture (−53%). Primary ventricular fibrillation showed no significant downslope trend.
Conclusions
In‐hospital STEMI complications and 28‐day and 1‐year mortality rates have dropped markedly in the past 30 years. Reducing ischemia‐driven primary ventricular fibrillation remains a major challenge.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine
Cited by
17 articles.
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