Head-up Tilt Test

Abstract

Background Patients with bifascicular block have an increased risk of syncopal attacks, but the underlying mechanism often remains unclear despite an extensive diagnostic workup. The head-up tilt test has been established as an important diagnostic tool in the unmasking of vasovagal syncope in patients with unexplained syncope. Its role in the evaluation of patients with bifascicular block has not been studied. Methods and Results A head-up tilt test, using a 60° angle of tilt for 45 minutes without pharmacological provocation, was performed in 25 patients with bifascicular block and syncope that remained unexplained after an extensive invasive and noninvasive electrophysiological investigation. As a control group, 25 subjects with bifascicular block without syncope, matched for age, sex, left ventricular function, and underlying heart disease, were included. A positive head-up tilt test was found in 7 (28%) of the syncope patients and in 8 (32%) of the control subjects ( P =NS). Six patients, of whom 3 had a positive tilt test, had recurrent syncopal attacks during 32 months of follow-up. None of the control subjects had syncope during follow-up. Conclusions This study gives rise to serious concern regarding the specificity of the head-up tilt test in patients with bifascicular block. A head-up tilt test should therefore be interpreted with caution, and its role as a diagnostic tool in this patient category remains to be established.