Glomerular Hyperfiltration, High Renin, and Low- Extracellular Volume in High Blood Pressure

Author:

Harrap Stephen B.1,Cumming Allan D.1,Davies David L.1,Foy Christopher J. W.1,Fraser Robert1,Kamitani Atsushi1,Connor J. Michael1,Lever Anthony F.1,Watt Graham C. M.1

Affiliation:

1. From the Department of Physiology (S.B.H., A.K.), The University of Melbourne, Parkville, Victoria, Australia; the MRC Blood Pressure Unit (R.F., A.F.L.) and the Department of Medicine & Therapeutics (D.L.D.), Western Infirmary, Glasgow, UK; the Department of Medicine (A.D.C.), Royal Infirmary, Edinburgh, UK; the Northern Regional Health Authority (C.J.W.F.), Newcastle upon Tyne, UK; Duncan Guthrie Institute of Medical Genetics (J.M.C.), Yorkhill, Glasgow, UK; and the Department of Public...

Abstract

Abstract —Abnormal renovascular resistance and glomerular filtration rate are characteristic of established hypertension and may also be involved in its pathogenesis. To determine renal and body fluid correlates of the predisposition to high blood pressure, we examined 100 healthy young adults with high or low blood pressure. Within each group, half had parents with high blood pressures, and half had parents with low blood pressures. Renal function and hemodynamics, body fluid volumes, and relevant hormones and genotypes were measured. Subjects with high personal and parental blood pressures had the highest levels of glomerular filtration rate ( P <0.02) and plasma active renin concentration and low levels of exchangeable sodium and plasma volume ( P <0.02). High glomerular filtration rate was not associated with differences in urinary kallikrein or prostaglandins. Polymorphisms of the renin, angiotensin-converting enzyme, and angiotensinogen genes were not associated with differences in glomerular filtration rate or renin. Subjects with high personal, but low parental, blood pressures had low exchangeable sodium and plasma volumes ( P <0.02) but normal glomerular filtration rates. In this population, extracellular volume depletion and high renin are correlates of high blood pressure in early adulthood, and glomerular hyperfiltration is a feature of those who also have familial predisposition to high blood pressure.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Internal Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3