ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb

Author:

Blackwood Erik A.1,Hofmann Christoph123,Santo Domingo Michelle1,Bilal Alina S.1,Sarakki Anup1,Stauffer Winston1,Arrieta Adrian1,Thuerauf Donna J.1,Kolkhorst Fred W.1,Müller Oliver J.234,Jakobi Tobias235,Dieterich Christoph235,Katus Hugo A.23,Doroudgar Shirin23,Glembotski Christopher C.1

Affiliation:

1. From the Department of Biology, San Diego State University Heart Institute, San Diego State University, CA (E.A.B., C.H., M.S.D., A.S.B., A.S., W.S., A.A., D.J.T., F.W.K., C.C.G.)

2. Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, Germany (C.H., O.J.M., H.A.K., S.D.)

3. German Centre for Cardiovascular Research, Partner Site Heidelberg (C.H., O.J.M., T.J., C.D., H.A.K., S.D.)

4. Department of Internal Medicine III, University of Kiel, Germany, and German Centre for Cardiovascular Research, Partner Site Hamburg/Kiel/Lübeck, Germany (O.J.M.)

5. Section of Bioinformatics and Systems Cardiology, Department of Internal Medicine III, University Hospital Heidelberg, Germany (T.J., C.D.).

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine,Physiology

Reference48 articles.

1. Adapting Proteostasis for Disease Intervention

2. Roles for the sarco-/endoplasmic reticulum in cardiac myocyte contraction, protein synthesis, and protein quality control.;Glembotski CC;Physiology (Bethesda),2012

3. Orchestration of secretory protein folding by ER chaperones

4. Roles for ATF6 and the sarco/endoplasmic reticulum protein quality control system in the heart

5. ER protein quality control and the unfolded protein response in the heart.;Arrieta A;Curr Top Microbiol Immunol,2018

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