Age‐Related Differences in Takotsubo Syndrome: Results From the Multicenter GEIST Registry-Reference-Cited by-同舟云学术

Age‐Related Differences in Takotsubo Syndrome: Results From the Multicenter GEIST Registry

Published:2024-02-20 Issue:4 Volume:13 Page:
ISSN:2047-9980
Container-title:Journal of the American Heart Association
language:en
Short-container-title:JAHA

Author:

El‐Battrawy Ibrahim¹²^ORCID,Santoro Francesco³,Núñez‐Gil Iván J.⁴^ORCID,Pätz Toni⁵^ORCID,Arcari Luca⁶^ORCID,Abumayyaleh Mohammad¹⁷^ORCID,Guerra Federico⁸,Novo Giuseppina⁹^ORCID,Musumeci Beatrice¹⁰^ORCID,Cacciotti Luca¹¹^ORCID,Mariano Enrica¹²^ORCID,Caldarola Pasquale¹³,Parisi Giuseppe¹⁴^ORCID,Montisci Roberta¹⁵^ORCID,Vitale Enrica³^ORCID,Volpe Massimo¹⁰^ORCID,Corbì‐Pasqual Miguel¹⁶,Martinez‐Selles Manuel¹⁷¹⁸^ORCID,Almendro‐Delia Manuel¹⁹^ORCID,Sionis Alessandro²⁰^ORCID,Uribarri Aitor²¹⁷^ORCID,Thiele Holger²²^ORCID,Brunetti Natale Daniele³^ORCID,Eitel Ingo⁵^ORCID,Akin Ibrahim²³^ORCID,Stiermaier Thomas⁵^ORCID

Affiliation:

1. Institute of Physiology, Department of Cellular and Translational Physiology and Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology Ruhr University Bochum, Bochum, Germany Bochum Germany

2. Department of Cardiology and Angiology Bergmannsheil University Hospitals, Ruhr University of Bochum Bochum Germany

3. Department of Medical and Surgical Sciences University of Foggia Foggia Italy

4. Interventional, Cardiology Cardiovascular Institute, Hospital Clínico Universitario San Carlos Madrid Spain

5. Medical Clinic II (Cardiology/Angiology/Intensive Care Medicine) and German Center for Cardiovascular Research, partner site Hamburg/Kiel/Lübeck University Heart Center Lübeck Lübeck Germany

6. Institute of Cardiology Madre Giuseppina Vannini Hospital Rome Italy

7. CIBERCV Madrid Spain

8. Cardiology and Arrhythmology Clinic Marche Polytechnic University, University Hospital “Umberto I—Lancisi—Salesi” Ancona Italy

9. Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Cardiology Unit University of Palermo, University Hospital P. Giaccone Palermo Italy

10. Cardiology, Clinical and Molecular Medicine Department, Faculty of Medicine and Psychology Sapienza University of Rome Rome Italy

11. Cardiology Unit Madre Giuseppina Vannini Hospital Rome Italy

12. Division of Cardiology University of Rome Tor Vergata Rome Italy

13. Department of Cardiology San Paolo Hospital Bari Italy

14. Pediatric Respiratory Unit, Department of Clinical and Experimental Medicine, San Marco Hospital University of Catania Catania Italy

15. Clinical Cardiology, Department of Medical Science and Public Health University of Cagliari Cagliari Italy

16. Department of Cardiology Complejo Hospitalario de Albacete Albacete Spain

17. Department of Cardiology Hospital General Universitario Gregorio Marañon, Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares Madrid Spain

18. Universidad Europea, Universidad Complutense Madrid Spain

19. Servicio de Cardiología Hospital Virgen de la Macarena Sevilla Spain

20. Unidad de Cuidados Intensivos Cardiológicos, Servicio de Cardiología, Hospital de Sant Pau, Instituto de Investigación Biomédica Sant Pau (IIB Sant Pau) Barcelona Spain

21. Cardiology Service, Vall d’Hebron University Hospital Barcelona Spain

22. Department of Internal Medicine/Cardiology Heart Center Leipzig at University of Leipzig and Leipzig Heart Institute Leipzig Germany

23. University of Mannheim Mannheim Germany

Abstract

Background The role of age in the short‐ and long‐term prognosis of takotsubo syndrome (TTS) is controversial. The aim of the present study was to evaluate age‐related differences and prognostic implications among patients with TTS. Methods and Results In total, 2492 consecutive patients with TTS enrolled in an international registry were stratified into 4 groups (<45, 45–64, 65–74, and ≥75 years). The median long‐term follow‐up was 480 days (interquartile range, 83–1510 days). The primary outcome was all‐cause mortality (in‐hospital and out‐of‐hospital mortality). The secondary end point was TTS‐related in‐hospital complications. Among the 2479 patients, 58 (2.3%) were aged <45 years, 625 (25.1%) were aged 45 to 64 years, 733 (29.4%) were aged 65 to 74 years, and 1063 (42.6%) were aged ≥75 years. Young patients (<45 years) had a higher prevalence of men (from youngest to oldest, 24.1% versus 12.6% versus 9.7% versus 11.4%; P <0.01), physical triggers (46.6% versus 27.5%, 33.9%, and 38.4%; P <0.01), and non‐apical forms of TTS (25.9% versus 23.7%, 12.7%, and 9%; P <0.01) than those aged 45 to 64, 65 to 74, and ≥75 years. During hospitalization, young patients experienced a higher rate of in‐hospital complications (32.8% versus 23.4%, 27.4%, and 31.9%; P =0.01), but in‐hospital mortality was higher in the older group (0%, 1.6%, 2.9%, and 5%; P =0.001). Long‐term all‐cause mortality was significantly higher in the older cohort (5.6%, 6.4%, 11.3%, and 22.3%; log‐rank P <0.001), as was long‐term cardiovascular mortality (0%, 0.9%, 1.9%, and 3.2%; log‐rank P =0.01). Conclusions Young patients with TTS have a typical phenotype characterized by a higher prevalence of male sex, non‐apical ballooning patterns, and in‐hospital complications. However, in‐hospital and long‐term mortality are significantly lower in young patients with TTS. Registration URL: https://classic.clinicaltrials.gov/ct2/show/NCT04361994 . Unique identifier: NCT04361994.

Publisher

Ovid Technologies (Wolters Kluwer Health)

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