Affiliation:
1. Department of Medicine, Harvard Medical School, and Peter Bent Brigham Hospital Boston, Massachusetts 02115 Department of Cardiology, Cedars-Sinai Medical Center Los Angeles, California 90025
Abstract
A sensitive method was developed for detecting stiffness changes in the left ventricle. Stress-strain relationships (σ--ε) were obtained in the form dσ/dε = kσ +
c
from published studies on eight normal canine hearts, five infarcted canine hearts, and seven isolated cat papillary muscles. Utilizing pressure-volume relationships, the elastic stiffness (dσ/dε) and the stiffness constant (
k
) were also evaluated in patients with normal ventricles, inappropriate hypertrophy, and congestive cardiomyopathy. The
k
values were 35.0 ± 1.7 (isolated muscle, 30°C), 37.3 ± 1.9 (normal canine, 23°C), and 23.9 (infarcted). For the patient groups,
k
and the passive elastic stiffness were 15.8 ± 0.3 and 249 ± 22.4 g/cm
2
for 13 normal patients, 26.4 ± 1.7 and 286 ± 32.0 g/cm
2
for 7 patients with inappropriate hypertrophy, and 20.1 ± 1.2 and 1360 ± 209 g/cm
2
for 6 patients with congestive cardiomyopathy. The results indicate that (1)
k
is sensitive to stiffness changes due to infarction, (2) hypertrophy causes an increase in the value of
k
although elastic stiffness remains within normal limits, and (3)
k
for the intact human heart is lower than it is for isolated muscle.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Subject
Cardiology and Cardiovascular Medicine,Physiology
Reference35 articles.
1. BBISTOW J.D. VAN ZEE B.E. AND JUDKINS Systolic and diastolic abnormalities M.P.:
2. of the left
3. ventricle in coronary artery disease: Studies in
4. patients with little or no enlargement of ventricular
Cited by
373 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献