1. From the Department of Pharmacotherapeutics (A.K., Y.I., T.K., T.S., N.M., Y.Y., A.Y., and S.M.), Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan; the Department of Ophthalmology (F.G.), Graduate School of Medicine, Osaka University, Osaka, Japan; and the Laboratory of Molecular Neuropharmacology (N.S. and A.B.), Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.