Plasma protein changes in primary hypertension in humans and rats.

Author:

Cloix J F,Devynck M A,Brentano J L,Meyer P

Abstract

To determine whether plasma protein changes may be associated with primary hypertension, we analyzed plasma proteins from essential hypertensive (EHT) patients and genetically hypertensive rats using two-dimensional electrophoresis. An additional plasma protein, having a molecular weight of 13,000 daltons and an isoelectric point of 4.5, was found in 82% of the patients with borderline or moderate hypertension (n = 29) and in all permanently hypertensive patients (n = 12). This protein was detected in 36% of normotensive (NT) subjects (n = 50). In the latter, the influence of family history, sex, and secondary hypertension were studied. Plasma proteins were also studied in spontaneously hypertensive rats (SHR). In all plasma from young male (n = 10) and female (n = 6) SHR, two additional proteins (molecular weight = 16,000 daltons, pHi = 4.7 and 5.1) were detectable. These plasma proteins were not detectable in male Wistar Kyoto rats (WKY) and in 50% of female WKY, and their frequency was 10% (n = 10) and 0% (n = 3) in normal male WKY and in male WKY rendered hypertensive by methylprednisolone, respectively. We conclude that these alterations of plasma proteins may be considered a biochemical feature of primary hypertension.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Internal Medicine

Reference36 articles.

1. Untersuchungen zur Natrium-permeabitat der erythrocyten bei Hypertonikern und Normotonikem mit familiarer hochdruckbelastung;Wessel F;Z Kreislauf,1967

2. Increased erythrocytes sodium efflux in genetic hypertensive rats of the Hebrew University strain

3. Increased erythrocyte permeability to Li and Na in the spontaneously hypertensive rat

4. Evidence of altered permeability of the erythrocyte membrane for sodium and potassium ions in spontaneously hypertensive rats;Postnov YV;Clin Sci,1977

5. Glass electrode measurement of net Na+ and K+ fluxes in erythrocytes of the spontaneously hypertensive rat

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