1. From the Department of Medicine, Cardiovascular Research Laboratories, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada (A.D.S., Y.Q., C.J.M., R.H.L.W., R.S.K.); Molecular Structure and Function, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada (M.N., C.B., J.Z., K.A.); and Department of Biochemistry and Laboratory Medicine, University of Toronto, Toronto, Ontario, Canada (M.N., C.B., J.Z., K.A.).