1. From the Departments of Medicine (A.J.L.), Human Genetics (R.M.H., C.P., P.P., D.W.-V., R.M.C., A.J.L.), Microbiology and Molecular Genetics (N.A.K., N.S., A.J.L.), and Pediatrics (R.M.C.), David Geffen School of Medicine at UCLA, Los Angeles, Calif; the Department of Biochemistry (M.M., J.N.), University of Wisconsin-Madison; and the Department of Medicine and Cardiovascular Research Institute, Maastricht (T.W.A.d.B.), Academic Hospital, Maastricht, the Netherlands.