Progression of Carotid Intima-Media Thickness as Predictor of Vascular Events

Author:

Baldassarre Damiano1,Veglia Fabrizio1,Hamsten Anders1,Humphries Steve E.1,Rauramaa Rainer1,de Faire Ulf1,Smit Andries J.1,Giral Philippe1,Kurl Sudhir1,Mannarino Elmo1,Grossi Enzo1,Paoletti Rodolfo1,Tremoli Elena1

Affiliation:

1. From the Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy (D.B., R.P., E.T.); Centro Cardiologico Monzino, IRCCS, Milan, Italy (D.B., F.V., E.T.); Atherosclerosis Research Unit, Department of Medicine (A.H.), and Division of Cardiovascular Epidemiology, Institute of Environmental Medicine and Department of Cardiology (U.d.F.), Solna Karolinska Institutet, Stockholm, Sweden; British Heart Foundation Laboratories, Department of Medicine, University College of...

Abstract

Objective— To investigate whether several different measures of carotid intima-media thickness (IMT) progression are associated with subsequent vascular events and whether such associations are independent of baseline carotid atherosclerotic profile and Framingham risk factors. Approach and Results— A longitudinal cohort study (the Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European Population study) was performed in 7 centers in 5 European countries (Finland, France, Italy, the Netherlands, and Sweden). Three thousand four hundred eighty-two subjects (median age 64.1 years; 47.8% men) with ≥3 vascular risk factors were recruited and monitored for a postprogression median follow-up of 21.5 months, during which time 129 subjects experienced a first vascular event (incidence of 20.4 per 1000 person-years). The 15th month progression of mean and maximum carotid IMT of the left and right common carotids, bifurcations, internal carotid arteries, and their composite measures, as well as the fastest IMT max progression (Fastest-IMT max-progr ) detected in the whole carotid tree regardless of location, were used in statistical analyses. All carotid IMT measures showed significant progression during the first 15 months ( P <0.001), but only the Fastest-IMT max-progr was significantly associated with the risk of subsequent vascular events. The Fastest-IMT max-progr association persisted after Bonferroni correction for multiple comparisons and after adjustments for Framingham risk factors and pharmacological treatments (all P <0.005). The use of Framingham Risk Score in place of Framingham risk factors provided almost identical results ( P =0.003). Conclusions— The Fastest-IMT max-progr , a novel approach to assess carotid IMT progression, identifies focal increases of carotid IMT and, in contrast to other progression variables, is associated with cardiovascular risk.

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Cardiology and Cardiovascular Medicine

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