1. From the Department of Medicine (E.M.S., S.J.L.B., R.O.B.G.), Trial Coordination Center (H.L.H.), Department of Epidemiology & Statistics (J.G.M.B.), Department of Nephrology (P.E.d.J.), Department of Medicine, Department of Clinical Pharmacology (D.d.Z.), University Medical Center, Groningen, The Netherlands.